Supplier of: skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and skin care ingredients,  for DIY skin care and cosmetics, and homemade skin care products. 

BulkActives are DIY skin care suppliers of skin actives, cosmetic ingredients, cosmeceuticals, active ingredients, and standardized botanical extracts for diy skin care products and homemade cosmetics.

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Quercetin 99%

Product details

 

 

Assay: 99%

Botanical Source: Sophorae Japonica  "Genistin, genistein, rutin, kaempferol and quercetin are important bioactive constituents in Sophorae Japonica" Read more
Solubility: Dimethyl isosorbide, non-denatured ethanol, propylene glycol

Suggested percentage: 1% in 6% propylene glycol (as described in the full text of the UVB study quoted below)
Stability: The product is stable: 'Evaluation of Functional Stability of Quercetin as a Raw Material and in Different Topical Formulations by its Antilipoperoxidative Activity' Read PDF

Conditions of Instability: Excess heat

Incompatibility with various substances: Reactive with oxidizing agents, acids.

 
Storage: Store in cool and dry place. Keep away from direct strong light and heat.
Country of origin: China

Can a Flavonoid, Quercetin, Be an Effective Topical Acne Medication?

Paige N. Dubin, CALIFORNIA STATE SCIENCE FAIR, project number: S1414

" topical Quercetin solution for acne proved to be a tremendous success in decreasing inflammatory acne lesions and decreasing the bacterial count on facial skin of all my acne subjects. " Read more (PDF)

Quercetin 99% can be found as an ingredient in skin care formulations intended for acne treatments, antioxidant formulas, and in UV protection skin care recipes. It also has properties that may make it useful in scar cream products.

DISCLAIMER:Any statements about products sold by BulkActives have not been evaluated by the FDA.  Products sold by BulkActives are not intended to be used as nutritional supplements. Products sold by BulkActives are not intended to diagnose, treat, cure, or prevent any disease.

BulkActives: ingredients for DIY skin care and cosmetics
Quercetin





Quercetin in skin care: 

 

  • antioxidant
  • anti-inflammatory
  • anti-acne
  • scar care
  • sun damage protection

 

 

 

 

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Polyphenols & Flavonoids

 

Polyphenols comprise a dynamic group of approximately 8,000 compounds that are widely distributed in plants used for food.

 

Within the class of polyphenols are the flavonoids, naturally occurring plant pigments that are also known as bioflavonoids.

 

About Quercetin

 

Quercetin belongs to a group of plant pigments called flavonoids that give many fruits, flowers, and vegetables their color.

 

Flavonoids impart color to many fruits, vegetables, and flowers, and have also been found to possess numerous health benefits

 

Flavonoids, such as quercetin, are antioxidants, they scavenge damaging particles in the body known as free radicals, which damage cell membranes, tamper with DNA, and even cause cell death.

 

Antioxidants can neutralize free radicals and may reduce or even help prevent some of the damage they cause.

Onion Extract Gel references (full abstracts here)

 

17: Perez OA, Viera MH, Patel JK, Konda S, Amini S, Huo R, Zell D, Tadicherla S, Berman B. A comparative study evaluating the tolerability and efficacy of two topical therapies for the treatment of keloids and hypertrophic scars. J Drugs Dermatol. 2010 May;9(5):514-8. PubMed PMID: 20480794. preexisting 

16: Koc E, Arca E, Surucu B, Kurumlu Z. An open, randomized, controlled, comparative study of the combined effect of intralesional triamcinolone acetonide and onion extract gel and intralesional triamcinolone acetonide alone in the treatment of hypertrophic scars and keloids. Dermatol Surg. 2008 Nov;34(11):1507-14. Epub 2008 Sep 15. PubMed PMID: 18798752. preexisting 

15: Draelos ZD. The ability of onion extract gel to improve the cosmetic appearance of postsurgical scars. J Cosmet Dermatol. 2008 Jun;7(2):101-4. PubMed  PMID: 18482012. surgery  

14: Hosnuter M, Payasli C, Isikdemir A, Tekerekoglu B. The effects of onion extract on hypertrophic and keloid scars. J Wound Care. 2007 Jun;16(6):251-4. PubMed PMID: 17722521. preexisting  

13: Ho WS, Ying SY, Chan PC, Chan HH. Use of onion extract, heparin, allantoin gel in prevention of scarring in chinese patients having laser removal of tattoos: a  prospective randomized controlled trial. Dermatol Surg. 2006 Jul;32(7):891-6. PubMed PMID: 16875470. surgery   

12: Chung VQ, Kelley L, Marra D, Jiang SB. Onion extract gel versus petrolatum emollient on new surgical scars: prospective double-blinded study. Dermatol Surg. 2006 Feb;32(2):193-7. PubMed PMID: 16442038. surgery

 

 

Quercetin in skin care - research

 

Topically applied Quercetin may:

 

  • prevent or reduce UVA and UVB sun damage:[11] [10] [4] [3] [2] [1]

 

Quercetin for Keloid and Hypertrophic Scar Treatment

 

First,  we strongly suggest you read this excellent article on scar treatment:

 

Keloid and Hypertrophic Scar Treatment & Management by  Brian Berman, MD, PhD; Chief Editor: Dirk M Elston, MD

 

There are a few in vitro studies which indicate that Qurectin may be a suitable compound for the treatment and prevention of Keloid and Hypertrophic Scars [9] [8] [7] [6] [5]

 

Also, several randomized clinical trials have reported the efficacy of onion extract either for the prevention of keloid and hypertrophic scar development after surgery [15] [13] [12] or for the management of preexisting scars [17] [16] [14].

 

It should be noted that we, at BulkActives, do NOT recommend that you put a DIY skin care product on open or healing wounds. 

 

However, for the treatment of pre-existing scars you may want to try Quercetin, which is the active ingredient in onions.

Quercetin References (full abstracts here)

 

11: Vicentini FT, Simi TR, Del Ciampo JO, Wolga NO, Pitol DL, Iyomasa MM, Bentley  MV, Fonseca MJ. Quercetin in w/o microemulsion: in vitro and in vivo skin penetration and efficacy against UVB-induced skin damages evaluated in vivo. Eur  J Pharm Biopharm. 2008 Aug;69(3):948-57. Epub 2008 Jan 20. PubMed PMID: 18304790. 

10: Casagrande R, Georgetti SR, Verri WA Jr, Dorta DJ, dos Santos AC, Fonseca MJ.  Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice. J Photochem Photobiol B. 2006 Jul  3;84(1):21-7. Epub 2006 Feb 21. PubMed PMID: 16495072. 

9. Maha F. El Goweini, MD*; Nagwa M. Nour El Din, MD.  Effect of Quercetin on Excessive Dermal ScarringEgyptian Dermatology Online Journal 1 (1): 5, June 2005


8: Phan TT, Lim IJ, Chan SY, Tan EK, Lee ST, Longaker MT. Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma. 2004 Nov;57(5):1032-7. PubMed PMID: 15580028. 

7: Phan TT, Lim IJ, Sun L, Chan SY, Bay BH, Tan EK, Lee ST. Quercetin inhibits fibronectin production by keloid-derived fibroblasts. Implication for the treatment of excessive scars. J Dermatol Sci. 2003 Dec;33(3):192-4. PubMed PMID:  14643528.  

6: Phan TT, Sun L, Bay BH, Chan SY, Lee ST. Dietary compounds inhibit proliferation and contraction of keloid and hypertrophic scar-derived fibroblasts in vitro: therapeutic implication for excessive scarring. J Trauma. 2003 Jun;54(6):1212-24. PubMed PMID: 12813346.  

5: Phan TT, See P, Tran E, Nguyen TT, Chan SY, Lee ST, Huynh H. Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids. Br J Dermatol. 2003 Mar;148(3):544-52. PubMed PMID: 12653748.  

4: Kahraman A, Inal ME. Protective effects of quercetin on ultraviolet A light-induced oxidative stress in the blood of rat. J Appl Toxicol. 2002 Sep-Oct;22(5):303-9. PubMed PMID: 12355559.  

3: Erden Inal M, Kahraman A, Köken T. Beneficial effects of quercetin on oxidative stress induced by ultraviolet A. Clin Exp Dermatol. 2001 Sep;26(6):536-9. PubMed PMID: 11678884.  

2: Erden Inal M, Kahraman A. The protective effect of flavonol quercetin against  ultraviolet a induced oxidative stress in rats. Toxicology. 2000 Nov 23;154(1-3):21-9. PubMed PMID: 11118667.  

1: Skaper SD, Fabris M, Ferrari V, Dalle Carbonare M, Leon A. Quercetin protects cutaneous tissue-associated cell types including sensory neurons from oxidative stress induced by glutathione depletion: cooperative effects of ascorbic acid. Free Radic Biol Med. 1997;22(4):669-78. PubMed PMID: 9013129.